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Game preview:
The 49ers and Rams, both sitting at 3-1, clash this Thursday in a pivotal NFC West showdown at SoFi Stadium. With San Francisco battling injuries and Los Angeles riding a wave of offensive momentum, the Rams enter as 6.5-point favorites.
San Francisco started the season strong with wins over the Seahawks, Saints, and Cardinals, but their Week 4 loss to the Jaguars exposed some troubling trends. Quarterback Brock Purdy returned from injury only to throw two interceptions and lose a fumble, while the offense leaned heavily on Christian McCaffrey, who leads the league in touches but is averaging a career-low 5.3 yards per touch.
The 49ers are also missing key playmakers like George Kittle and Nick Bosa, and wide receivers Ricky Pearsall and Jauan Jennings are questionable heading into Thursday1. Their defense, once dominant, now ranks 29th in pressure rate and 25th in opponent completion percentage—a dangerous combination against a Rams team that thrives through the air.
Meanwhile, the Rams have looked increasingly formidable. After a narrow loss to the Eagles, they bounced back with a 27-20 win over the Colts, led by Matthew Stafford’s 1,114 passing yards and eight touchdowns through four games.
Rookie sensation Puka Nacua leads the NFL in receptions and receiving yards, while Davante Adams and Kyren Williams add depth to a potent offense. Defensively, the Rams boast a fierce pass rush led by Byron Young and Jared Verse, which could overwhelm a depleted 49ers offensive line4. With Stafford facing a struggling secondary and Purdy likely forced into a shootout, expect the Rams to control the tempo and capitalize on San Francisco’s vulnerabilities. Learn more on DraftKings .
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